Start2Fold

The database of hydrogen/deuterium exchange data on protein folding and stability

BROWSING RESIDUE SETS

Protection Level Molecular system Entry ID Type Experimental method Reference
EARLY Bovine alpha-lactalbumin (BLA) STF0007 folding HDX-folding competition by NMR PMID 10329172
STRONG Bovine alpha-lactalbumin (BLA) STF0007 stability Native exchange NMR PMID 10329172
WEAK Bovine alpha-lactalbumin (BLA) STF0007 stability Native exchange NMR PMID 10329172
STRONG Bovine alpha-lactalbumin (BLA) STF0007 stability Native exchange in partially folded state by NMR PMID 10329172
MEDIUM Bovine alpha-lactalbumin (BLA) STF0007 stability Native exchange in partially folded state by NMR PMID 10329172
WEAK Bovine alpha-lactalbumin (BLA) STF0007 stability Native exchange in partially folded state by NMR PMID 10329172
EARLY Equine lysozyme STF0013 folding HDX-folding competition by NMR PMID 10369782
INTERMEDIATE Equine lysozyme STF0013 folding HDX-folding competition by NMR PMID 10369782
LATE Equine lysozyme STF0013 folding HDX-folding competition by NMR PMID 10369782
STRONG G. gallus alpha-spectrin SH3 STF0053 stability Native exchange NMR PMID 10413463
MEDIUM G. gallus alpha-spectrin SH3 STF0053 stability Native exchange NMR PMID 10413463
STRONG Bacteriophage T4 lysozyme STF0021 stability Native exchange NMR PMID 10542101
MEDIUM Bacteriophage T4 lysozyme STF0021 stability Native exchange NMR PMID 10542101
WEAK Bacteriophage T4 lysozyme STF0021 stability Native exchange NMR PMID 10542101
EARLY Bovine beta-lactoglobulin (beta-LG) STF0005 folding Pulse labeling HDX NMR PMID 10686102
STRONG Bovine beta-lactoglobulin (beta-LG) STF0005 stability Native exchange NMR PMID 10686102
MEDIUM Bovine beta-lactoglobulin (beta-LG) STF0005 stability Native exchange NMR PMID 10686102
WEAK Bovine beta-lactoglobulin (beta-LG) STF0005 stability Native exchange NMR PMID 10686102
EARLY S54G/P55N-RNase T1 STF0019 folding HDX-folding competition by NMR PMID 10891071
INTERMEDIATE S54G/P55N-RNase T1 STF0019 folding HDX-folding competition by NMR PMID 10891071
LATE S54G/P55N-RNase T1 STF0019 folding HDX-folding competition by NMR PMID 10891071
STRONG S54G/P55N-RNase T1 STF0019 stability Native exchange NMR PMID 10891071
MEDIUM S54G/P55N-RNase T1 STF0019 stability Native exchange NMR PMID 10891071
STRONG Cardiotoxin III STF0037 stability Native exchange NMR PMID 10913281
MEDIUM Cardiotoxin III STF0037 stability Native exchange NMR PMID 10913281
STRONG Cobrotoxin (CBTX) STF0008 stability Native exchange NMR PMID 10913281
MEDIUM Cobrotoxin (CBTX) STF0008 stability Native exchange NMR PMID 10913281
EARLY Bovine acyl-coenzyme A binding protein (ACBP) STF0001 folding Quenched-flow HDX NMR PMID 10966822
EARLY Bovine acyl-coenzyme A binding protein (ACBP) STF0001 folding Quenched-flow HDX NMR PMID 10966822
INTERMEDIATE Bovine acyl-coenzyme A binding protein (ACBP) STF0001 folding Quenched-flow HDX NMR PMID 10966822
LATE Bovine acyl-coenzyme A binding protein (ACBP) STF0001 folding Quenched-flow HDX NMR PMID 10966822
EARLY Human acidic fibroblast growth factor 1 (hFGF-1) STF0024 folding Quenched-flow HDX NMR PMID 11038349
INTERMEDIATE Human acidic fibroblast growth factor 1 (hFGF-1) STF0024 folding Quenched-flow HDX NMR PMID 11038349
LATE Human acidic fibroblast growth factor 1 (hFGF-1) STF0024 folding Quenched-flow HDX NMR PMID 11038349
STRONG Nanobody from Lama glama STF0052 stability Native exchange NMR PMID 11141058
MEDIUM Nanobody from Lama glama STF0052 stability Native exchange NMR PMID 11141058
STRONG C-terminal domain of rat CD2 (CD2.D1) STF0009 stability Native exchange NMR PMID 11152615
MEDIUM C-terminal domain of rat CD2 (CD2.D1) STF0009 stability Native exchange NMR PMID 11152615
EARLY Bovine beta-lactoglobulin (beta-LG) STF0005 folding Burst phase labeling HDX NMR PMID 11175905
INTERMEDIATE Bovine beta-lactoglobulin (beta-LG) STF0005 folding Burst phase labeling HDX NMR PMID 11175905
LATE Bovine beta-lactoglobulin (beta-LG) STF0005 folding Burst phase labeling HDX NMR PMID 11175905
STRONG Bovine alpha-lactalbumin (BLA) STF0007 stability Native exchange NMR PMID 11273708
EARLY SNase H124L STF0020 folding Pulse labeling HDX NMR PMID 11742125
LATE SNase H124L STF0020 folding Pulse labeling HDX NMR PMID 11742125
STRONG Dictyostelium discoideum hisactophilin-1 STF0010 stability Native exchange NMR PMID 11802717
EARLY Dictyostelium discoideum hisactophilin-1 STF0010 folding Quenched-flow HDX NMR PMID 11847289
INTERMEDIATE Dictyostelium discoideum hisactophilin-1 STF0010 folding Quenched-flow HDX NMR PMID 11847289
LATE Dictyostelium discoideum hisactophilin-1 STF0010 folding Quenched-flow HDX NMR PMID 11847289
STRONG Redesigned apo-cytochrome b562 STF0036 stability Native exchange NMR PMID 12069590
MEDIUM Redesigned apo-cytochrome b562 STF0036 stability Native exchange NMR PMID 12069590
WEAK Redesigned apo-cytochrome b562 STF0036 stability Native exchange NMR PMID 12069590
STRONG Borrelia burgdorferi outer surface protein A (OspA) STF0034 stability Native exchange NMR PMID 12381326
MEDIUM Borrelia burgdorferi outer surface protein A (OspA) STF0034 stability Native exchange NMR PMID 12381326
WEAK Borrelia burgdorferi outer surface protein A (OspA) STF0034 stability Native exchange NMR PMID 12381326
STRONG Oxidized P. aeruginosa ferricytochrome c(551) STF0051 stability Native exchange NMR PMID 12459911
MEDIUM Oxidized P. aeruginosa ferricytochrome c(551) STF0051 stability Native exchange NMR PMID 12459911
STRONG Human acidic fibroblast growth factor 1 (hFGF-1) STF0024 stability Native exchange NMR PMID 12484774
MEDIUM Human acidic fibroblast growth factor 1 (hFGF-1) STF0024 stability Native exchange NMR PMID 12484774
EARLY Rabbit muscle aldolase STF0017 folding Pulse labeling HDX MS PMID 12741828
INTERMEDIATE Rabbit muscle aldolase STF0017 folding Pulse labeling HDX MS PMID 12741828
EARLY Ubiquitin STF0027 folding Pulse labeling HDX NMR PMID 1312711
LATE Ubiquitin STF0027 folding Pulse labeling HDX NMR PMID 1312711
STRONG Ubiquitin STF0027 stability Native exchange NMR PMID 1332757
STRONG Hen egg-white lysozyme STF0042 stability Native exchange NMR PMID 1409571
EARLY Rabbit muscle triosephosphate isomerase STF0032 folding Pulse labeling HDX MS PMID 15037083
LATE Rabbit muscle triosephosphate isomerase STF0032 folding Pulse labeling HDX MS PMID 15037083
STRONG Alpha-subunit of tryptophan synthase (aTS) STF0022 stability Native exchange in partially folded state by MS PMID 15312776
STRONG E.coli YOJN histidine-phosphotransferase domain STF0054 stability Native exchange NMR PMID 15476819
STRONG PDZ-3 from PSD-95 STF0035 stability Native exchange NMR PMID 15663949
MEDIUM PDZ-3 from PSD-95 STF0035 stability Native exchange NMR PMID 15663949
WEAK PDZ-3 from PSD-95 STF0035 stability Native exchange NMR PMID 15663949
EARLY Alpha-subunit of tryptophan synthase (aTS) STF0022 folding Pulse labeling HDX MS PMID 15784252
INTERMEDIATE Alpha-subunit of tryptophan synthase (aTS) STF0022 folding Pulse labeling HDX MS PMID 15784252
EARLY Hen egg-white lysozyme STF0042 folding Pulse labeling HDX NMR PMID 1641003
INTERMEDIATE Hen egg-white lysozyme STF0042 folding Pulse labeling HDX NMR PMID 1641003
EARLY Cobrotoxin (CBTX) STF0008 folding Quenched-flow HDX NMR PMID 16497267
INTERMEDIATE Cobrotoxin (CBTX) STF0008 folding Quenched-flow HDX NMR PMID 16497267
LATE Cobrotoxin (CBTX) STF0008 folding Quenched-flow HDX NMR PMID 16497267
STRONG Forkhead-associated (FHA) domain from Arabidopsis KAPP STF0033 stability Native exchange NMR PMID 17007879
MEDIUM Forkhead-associated (FHA) domain from Arabidopsis KAPP STF0033 stability Native exchange NMR PMID 17007879
WEAK Forkhead-associated (FHA) domain from Arabidopsis KAPP STF0033 stability Native exchange NMR PMID 17007879
EARLY Bacteriophage T4 lysozyme STF0021 folding Dead time pulse labeling HDX NMR PMID 17097105
INTERMEDIATE Bacteriophage T4 lysozyme STF0021 folding Dead time pulse labeling HDX NMR PMID 17097105
EARLY Sperm whale apo-myoglobin STF0004 folding Pulse labeling HDX NMR PMID 18779573
INTERMEDIATE Sperm whale apo-myoglobin STF0004 folding Pulse labeling HDX NMR PMID 18779573
LATE Sperm whale apo-myoglobin STF0004 folding Pulse labeling HDX NMR PMID 18779573
EARLY Apo-flavodoxin STF0030 folding Denaturant-dependent disappearance of amide cross peaks by NMR PMID 19170491
INTERMEDIATE Apo-flavodoxin STF0030 folding Denaturant-dependent disappearance of amide cross peaks by NMR PMID 19170491
STRONG P. aeruginosa PSE-4 beta-lactamase STF0055 stability Native exchange NMR PMID 19486690
MEDIUM P. aeruginosa PSE-4 beta-lactamase STF0055 stability Native exchange NMR PMID 19486690
EARLY Northern leopard frog onconase STF0015 folding Quenched-flow HDX NMR PMID 19655705
INTERMEDIATE Northern leopard frog onconase STF0015 folding Quenched-flow HDX NMR PMID 19655705
STRONG Northern leopard frog onconase STF0015 stability Native exchange NMR PMID 19655705
STRONG cellular retinol-binding protein type-1 STF0056 stability Native exchange NMR PMID 19965581
MEDIUM cellular retinol-binding protein type-1 STF0056 stability Native exchange NMR PMID 19965581
STRONG cellular retinol-binding protein type-2 STF0057 stability Native exchange NMR PMID 19965581
MEDIUM cellular retinol-binding protein type-2 STF0057 stability Native exchange NMR PMID 19965581
EARLY Hen egg-white lysozyme STF0042 folding HDX-folding competition by NMR PMID 2000138
EARLY Bacteriophage lambda lysozyme STF0006 folding Pulse labeling HDX NMR and MS PMID 20806781
INTERMEDIATE Bacteriophage lambda lysozyme STF0006 folding Pulse labeling HDX NMR and MS PMID 20806781
LATE Bacteriophage lambda lysozyme STF0006 folding Pulse labeling HDX NMR and MS PMID 20806781
STRONG Bacteriophage lambda lysozyme STF0006 stability Native exchange NMR PMID 20806781
MEDIUM Bacteriophage lambda lysozyme STF0006 stability Native exchange NMR PMID 20806781
WEAK Bacteriophage lambda lysozyme STF0006 stability Native exchange NMR PMID 20806781
EARLY Horse apo-myoglobin STF0003 folding Pulse labeling HDX MS PMID 20849085
INTERMEDIATE Horse apo-myoglobin STF0003 folding Pulse labeling HDX MS PMID 20849085
STRONG Horse apo-myoglobin STF0003 stability Native exchange MS PMID 20849085
MEDIUM Horse apo-myoglobin STF0003 stability Native exchange MS PMID 20849085
WEAK Horse apo-myoglobin STF0003 stability Native exchange MS PMID 20849085
EARLY Human acidic fibroblast growth factor 1 (hFGF-1) STF0024 folding Denatured state HDX NMR PMID 21190667
INTERMEDIATE Human acidic fibroblast growth factor 1 (hFGF-1) STF0024 folding Denatured state HDX NMR PMID 21190667
LATE Human acidic fibroblast growth factor 1 (hFGF-1) STF0024 folding Denatured state HDX NMR PMID 21190667
STRONG Horse ferricytochrome c STF0023 stability Native exchange NMR PMID 2176867
MEDIUM Horse ferricytochrome c STF0023 stability Native exchange NMR PMID 2176867
STRONG Horse ferricytochrome c STF0023 stability Native exchange in partially folded state by NMR PMID 2176867
MEDIUM Horse ferricytochrome c STF0023 stability Native exchange in partially folded state by NMR PMID 2176867
EARLY C-terminal domain of the Fas-associated death domain STF0025 folding Quenched-flow HDX NMR PMID 22130896
STRONG C-terminal domain of the Fas-associated death domain STF0025 stability Native exchange NMR PMID 22130896
MEDIUM C-terminal domain of the Fas-associated death domain STF0025 stability Native exchange NMR PMID 22130896
STRONG Sperm whale apo-myoglobin STF0004 stability Native exchange NMR PMID 2218495
MEDIUM Sperm whale apo-myoglobin STF0004 stability Native exchange NMR PMID 2218495
STRONG Sperm whale apo-myoglobin STF0004 stability Native exchange in partially folded state by NMR PMID 2218495
MEDIUM Sperm whale apo-myoglobin STF0004 stability Native exchange in partially folded state by NMR PMID 2218495
EARLY Ribonuclease A STF0046 folding Pulse labeling HDX NMR PMID 2236032
INTERMEDIATE Ribonuclease A STF0046 folding Pulse labeling HDX NMR PMID 2236032
EARLY Human alpha1-antitrypsin STF0031 folding Pulse labeling HDX MS PMID 22392975
EARLY Human alpha1-antitrypsin STF0031 folding Oxidative labeling MS PMID 22940366
LATE Human alpha1-antitrypsin STF0031 folding Oxidative labeling MS PMID 22940366
STRONG E. coli apo-maltose binding protein (apo-MBP) STF0002 stability Native exchange NMR PMID 23046344
MEDIUM E. coli apo-maltose binding protein (apo-MBP) STF0002 stability Native exchange NMR PMID 23046344
EARLY E. coli RNase HI STF0018 folding Pulse labeling HDX MS PMID 23603271
INTERMEDIATE E. coli RNase HI STF0018 folding Pulse labeling HDX MS PMID 23603271
LATE E. coli RNase HI STF0018 folding Pulse labeling HDX MS PMID 23603271
STRONG Interleukin-1b subunit STF0043 stability Native exchange NMR PMID 2372550
EARLY E. coli apo-maltose binding protein (apo-MBP) STF0002 folding Pulse labeling HDX MS PMID 24191053
INTERMEDIATE E. coli apo-maltose binding protein (apo-MBP) STF0002 folding Pulse labeling HDX MS PMID 24191053
EARLY Horse ferricytochrome c STF0023 folding HDX-folding competition by NMR PMID 24364692
INTERMEDIATE Horse ferricytochrome c STF0023 folding HDX-folding competition by NMR PMID 24364692
LATE Horse ferricytochrome c STF0023 folding HDX-folding competition by NMR PMID 24364692
STRONG Tendamistat STF0047 stability Native exchange NMR PMID 2827730
EARLY Bovine pancreatic trypsin inhibitor STF0038 folding HDX-folding competition by NMR PMID 2835760
EARLY Horse ferricytochrome c STF0023 folding Pulse labeling HDX NMR PMID 2845279
STRONG French bean apoplastocyanin STF0012 stability Native exchange NMR PMID 3172230
STRONG Bovine pancreatic trypsin inhibitor STF0038 stability Native exchange NMR PMID 7248461
STRONG Alpha-lactalbumin (human) STF0049 stability Native exchange NMR PMID 7473740
STRONG Alpha-lactalbumin (human) STF0049 stability Native exchange in partially folded state by NMR PMID 7473740
STRONG Ribonuclease A STF0046 stability Native exchange NMR PMID 7578123
STRONG B1 immunoglobulin-binding domain of streptococcal protein G STF0040 stability Native exchange NMR PMID 7578145
MEDIUM B1 immunoglobulin-binding domain of streptococcal protein G STF0040 stability Native exchange NMR PMID 7578145
STRONG Bovine acyl-coenzyme A binding protein (ACBP) STF0001 stability Native exchange NMR PMID 7623386
MEDIUM Bovine acyl-coenzyme A binding protein (ACBP) STF0001 stability Native exchange NMR PMID 7623386
STRONG Bacillus amyloliquefaciens ribonuclease STF0041 stability Native exchange NMR PMID 7626599
EARLY B1 immunoglobulin-binding domain of streptococcal protein G STF0040 folding Quenched-flow HDX NMR PMID 7703841
EARLY E. coli dihydrofolate reductase (DHFR) STF0011 folding Pulse labeling HDX NMR PMID 7757007
INTERMEDIATE E. coli dihydrofolate reductase (DHFR) STF0011 folding Pulse labeling HDX NMR PMID 7757007
LATE E. coli dihydrofolate reductase (DHFR) STF0011 folding Pulse labeling HDX NMR PMID 7757007
STRONG E. coli dihydrofolate reductase (DHFR) STF0011 stability Native exchange NMR PMID 7757007
STRONG Villin 14T STF0028 stability Native exchange NMR PMID 8075541
MEDIUM Villin 14T STF0028 stability Native exchange NMR PMID 8075541
EARLY Human lysozyme STF0014 folding Pulse labeling HDX NMR PMID 8180215
INTERMEDIATE Human lysozyme STF0014 folding Pulse labeling HDX NMR PMID 8180215
LATE Human lysozyme STF0014 folding Pulse labeling HDX NMR PMID 8180215
EARLY Horse ferricytochrome c STF0023 folding Pulse labeling HDX NMR PMID 8204626
STRONG SNase H124L STF0020 stability Native exchange NMR PMID 8218167
EARLY French bean apoplastocyanin STF0012 folding HDX-folding competition by NMR PMID 8241116
INTERMEDIATE French bean apoplastocyanin STF0012 folding HDX-folding competition by NMR PMID 8241116
LATE French bean apoplastocyanin STF0012 folding HDX-folding competition by NMR PMID 8241116
EARLY Interleukin-1b subunit STF0043 folding Quenched-flow HDX NMR PMID 8493553
INTERMEDIATE Interleukin-1b subunit STF0043 folding Quenched-flow HDX NMR PMID 8493553
STRONG Alpha-lactalbumin (guinea pig) STF0048 stability Native exchange in partially folded state by NMR PMID 8504087
EARLY S54G/P55N-RNase T1 STF0019 folding Pulse labeling HDX NMR PMID 8512924
INTERMEDIATE S54G/P55N-RNase T1 STF0019 folding Pulse labeling HDX NMR PMID 8512924
EARLY E. coli RNase HI STF0018 folding HDX-folding competition by NMR PMID 8527428
INTERMEDIATE E. coli RNase HI STF0018 folding HDX-folding competition by NMR PMID 8527428
STRONG Turkey ovomucoid third domain (OMTKY3) STF0016 stability Native exchange NMR PMID 8555171
STRONG Tendamistat STF0047 stability Native exchange in partially folded state by NMR PMID 8757805
STRONG B1 immunoglobulin-binding domain of peptostreptococcal protein L STF0044 stability Native exchange NMR PMID 8762137
STRONG E. coli RNase HI STF0018 stability Native exchange NMR PMID 8784352
STRONG Equine lysozyme STF0013 stability Native exchange NMR PMID 9180380
MEDIUM Equine lysozyme STF0013 stability Native exchange NMR PMID 9180380
STRONG Chymotrypsin Inhibitor 2 STF0039 stability Native exchange NMR PMID 9231903
MEDIUM Chymotrypsin Inhibitor 2 STF0039 stability Native exchange NMR PMID 9231903
STRONG S54G/P55N-RNase T1 STF0019 stability Native exchange NMR PMID 9232639
MEDIUM S54G/P55N-RNase T1 STF0019 stability Native exchange NMR PMID 9232639
STRONG Protein A B-domain STF0045 stability Native exchange NMR PMID 9232646
EARLY Protein A B-domain STF0045 folding Pulse labeling HDX NMR PMID 9232646
STRONG Chemotactic protein Chey STF0050 stability Native exchange NMR PMID 9268672
MEDIUM Chemotactic protein Chey STF0050 stability Native exchange NMR PMID 9268672
WEAK Chemotactic protein Chey STF0050 stability Native exchange NMR PMID 9268672
EARLY Turkey ovomucoid third domain (OMTKY3) STF0016 folding pH-dependent HDX NMR PMID 9289014
INTERMEDIATE Turkey ovomucoid third domain (OMTKY3) STF0016 folding pH-dependent HDX NMR PMID 9289014
LATE Turkey ovomucoid third domain (OMTKY3) STF0016 folding pH-dependent HDX NMR PMID 9289014
EARLY C-terminal domain of rat CD2 (CD2.D1) STF0009 folding HDX-folding competition by NMR PMID 9341233
INTERMEDIATE C-terminal domain of rat CD2 (CD2.D1) STF0009 folding HDX-folding competition by NMR PMID 9341233
LATE C-terminal domain of rat CD2 (CD2.D1) STF0009 folding HDX-folding competition by NMR PMID 9341233
EARLY B1 immunoglobulin-binding domain of peptostreptococcal protein L STF0044 folding Dead time pulse labeling HDX NMR PMID 9377710
STRONG Barstar STF0029 stability Native exchange NMR PMID 9517545
MEDIUM Barstar STF0029 stability Native exchange NMR PMID 9517545
STRONG E. coli RNase HI STF0018 stability Native exchange NMR PMID 9533889
EARLY Cardiotoxin III STF0037 folding Quenched-flow HDX NMR PMID 9553067
INTERMEDIATE Cardiotoxin III STF0037 folding Quenched-flow HDX NMR PMID 9553067
LATE Cardiotoxin III STF0037 folding Quenched-flow HDX NMR PMID 9553067
STRONG Rabbit muscle aldolase STF0017 stability Native exchange MS PMID 9572840
MEDIUM Rabbit muscle aldolase STF0017 stability Native exchange MS PMID 9572840
STRONG Apo-flavodoxin STF0030 stability Native exchange NMR PMID 9737928
EARLY Villin 14T STF0028 folding Quenched-flow HDX NMR PMID 9772179
EARLY RNase H domain from HIV-1 reverse transcriptase STF0026 folding Pulse labeling HDX NMR PMID 9792104
INTERMEDIATE RNase H domain from HIV-1 reverse transcriptase STF0026 folding Pulse labeling HDX NMR PMID 9792104
STRONG RNase H domain from HIV-1 reverse transcriptase STF0026 stability Native exchange NMR PMID 9792104